Recent，The School of Electrical Engineering discharge plasma and its biomedical application team in the field of cross -research in the atmospheric pressure low temperature, etc.，Research results are based on the "Molecular Dynamics Simulations of Cancer Cell Membrane Electropy Under the Plasma Electric Field Effect" and "Numerical Study On Intera CTIONS of Atmospheric Plasmas and Peptides by Reactive Molecular Dynamic Simulations "is the title，Posted on the international authoritative journal "Plasma Processes and Polymers"，and was selected by the journal in February and March of the journal in a row，Team Master Graduate Wang Huichao and Ding Yunhan are the first author，Professor Zhao Tong and Associate Professor Wang Xiaolong are communication authors，This research work has been jointly funded by the National Natural Science Foundation of China and the Shandong Natural Science Foundation。
Since the 21st century，Plasma biomedical as a typical cutting -edge cross -disciplinary discipline quickly rise，Involved in plasma physics、Life Science and Clinical Medicine and other fields，Among them, the treatment of auxiliary cancer is the hotspot and difficulty of plasma biomedical research。Plasma active particles need to be used through the cell membrane to act on the internal cancer cells，This plays the role of apoptosis cancer cells。"Molecular Dynamics Simulations of Cancer Cell Membrane Electropy Under the Plasma Electric Field Effect" Application of Classic Molecular Dynamics Model，Research found that under the effect of plasma electric field，Cancer cell membranes will occur in the phenomenon of perforation，Cause changes in the permeability of cell membrane，Promoting active substance transmissions transfers into the cell，Then induces cancer cell apoptosis。Hengdian Electric Farm、nano -second pulse electric field、Picxide pulse venue can cause the perforation of the cell membrane，The formation of hydrophilic channels between phospholipid biomolecular layers is a necessary condition for electric perforation。Plasma selective apoptosis cancer cells are the important cause of cancer cell membrane cholesterol content that affects the pitch threshold of electricity piercing，This is easier to form pores。This study reveals the micro -mechanism of the selective entered the cancer cells of the plasma active particles，For plasma provides an explanation of the mechanism of molecular leveling at the same time when the plasma is survived。
Plasma active particles can react with most biomolecular molecules after entering the cells，It acts after the internal protein of the cell and will be oxidized and accompanied by changes in configuration，This oxidation decoration effect is similar to that of protein translation in the organism，It will have an important impact on the function and life of protein。However, the current micro mechanism of plasma modified protein is still unclear，Become a research difficulty in the field of plasma medical medicine。"Numerical Study on Interactions of Atracy OF ATMOSPHERIC PEPTIDES BY Reactive Molecular Dynamic Simulatings" Choose four types of strong oxidation、Plasma active ions with a long life (O、oh、O3, h2O2) and protein polypeptide chain as research object，Combining the reaction molecular dynamic simulation method with the liquid chromatography-mass spectrometry experiment method，Study a micro -reaction mechanism for plasma and polypeptide chain。Research Discovery，After the plasma is treated with plasma，The introduction of oxygen atom in the polypeptide's side chain is the most common modification response，and at the same time observed dehydrogenation、sulfide、Hydroxylated、羰、Nitrobylization and ring cracks and other reaction types，Changes in the structure of these molecular structures will affect the folding of protein，Cause changes in protein function，thereby interfere with the cell signal transmission process and cause the apoptosis of cells。This study explains the oxidation modification and loss mechanism of plasma interaction between plasma and protein，It has important scientific significance。
Non -balanced atmospheric pressure discharging plasma Due to the modification of the material surface、Environment、Sewage treatment、Biomedical potential applications have received great attention。The development of plasma medicine in recent years is very fast，Provides new ideas for medical treatment for many diseases、New ways and new technologies，At the same time，The generation and optimization of discharge plasma also put forward higher requirements。Discharge plasma and its biomedical application team，Aiming at the cutting -edge problems of attention at home and abroad，Deepen the simulation of simulation research and corresponding experimental verification of the basic theory of the plasma ions，Focus on the nature of the active particles of the ionic body and the mechanism of the role of related biomass，Actively expand cross -disciplinary fusion in more fields，and Shandong University Medical College、Pharmacy、Qilu Hospital、Multi -Units of Shan University and other units in depth cooperation，A series of innovative research results have been achieved in the cross -medical industry，Active contribution to the further development of plasma medicine。
Related links: https://onlinelibrary.wiley.com/toc/16128869/2023/20/2
https://onlinelibrary.wiley.com/toc/16128869/2023/20/3
